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Exploratory analyses of a phase 3 trial comparing infliximab-qbtx to reference infliximab in patients with rheumatoid arthritis (RA) indicate that multibiomarker disease activity score may be used as an assessment of biosimilarity instead of conventional disease activity measures.

Interim results from the phase 3 TROIKA trial demonstrate clinical equivalence between the biosimilar HD201 and trastuzumab reference in terms of efficacy, safety, pharmacokinetics, and immunogenicity in patients with HER2-positive early breast cancer.

Real-world data indicate the efficacy and safety profile of the biosimilar trastuzumab-dttb + pertuzumab was consistent with that previously reported for trastuzumab reference + pertuzumab in patients with HER2-positive breast cancer.

Results of a placebo-controlled, randomized phase 2 trial indicate that maintenance treatment with lanreotide autogel (LAN) following first-line treatment may provide clinical benefit in aggressive grade 1 and 2, well-differentiated, duodeno-pancreatic neuroendocrine tumors (NETs).

Real-world safety data from the US expanded access program of Lu-DOTATATE showed that the safety profile was consistent with that previously described in clinical trials of patients with advanced midgut neuroendocrine tumors (NETs).

Findings of a retrospective analysis in patients with metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs) indicate that peptide receptor radionuclide therapy (PRRT) with Lu-DOTATATE may provide clinical benefit and does not significantly impair health-related quality of life (HRQoL).

Findings of a retrospective analysis of real-world data indicate that retreatment with 2 extra cycles of peptide receptor radionuclide therapy (PRRT) with Lu-DOTATATE provided survival benefit in patients with disease progression after initial PRRT.

Subgroup analysis data of the randomized phase 3 SANET-ep trial indicate that the clinical benefits of the multitargeted tyrosine kinase inhibitor surufatinib therapy also extended to major subgroups by Ki67 and primary tumor origin in patients with advanced, well-differentiated extrapancreatic neuroendocrine tumors (NETs).

Results of a dose-escalation/expansion study in the US population among patients with extrapancreatic and pancreatic neuroendocrine tumors (NETs) indicate promising antitumor activity of the multitargeted tyrosine kinase inhibitor surufatinib, with a safety profile consistent with that previously described in the SANET-ep trial.