2021 Year in Review: Non–Small-Cell Lung Cancer

The COVID-19 pandemic continues to impact healthcare across the globe. We are yet to see the full effect of the COVID-19 pandemic on patients with cancer, including patients with non–small-cell lung cancer (NSCLC). With the recent emergence of the COVID-19 Omicron variant, we expect this impact on healthcare and cancer care to continue. The Year in Review series is an important tool to reach audiences and provide timely and relevant information on treatment advances in the oncology setting.
Multidisciplinary tumor board members work closely to make the best clinical decisions for their patients with cancer to improve patient and institutional outcomes. Their decisions should be based on the clinical data of each patient in line with their own clinical and institutional guidelines.
Immunotherapy and targeted therapy have resulted in improved survival rates in patients with NSCLC over the past decade.
Sotorasib showed encouraging anticancer activity in phase 2 of a clinical trial of patients with heavily treated advanced NSCLC.
Data from the CodeBreaK 100 NSCLC subset population prompted the FDA to grant sotorasib accelerated approval for patients with KRASG12C mutation–positive NSCLC.
Finding the right balance between cancer-induced fatigue and immune-oncology–induced fatigue and doing enough exercise to improve general health and better cancer outcomes is a fundamental part of treating patients with cancer. Finding this balance for patients with NSCLC receiving immune-oncology therapy is a key element of overall care for these patients.
Diabetes is associated with increased risk for a number of cancers, including NSCLC. Patients with hyperglycemic NSCLC treated with pembrolizumab show poorer PFS and earlier tumor progression when compared with NSCLC patients with normal blood glucose levels.
Patients with NSCLC who are positive for KRASG12C have distinct imaging patterns from patients with other NSCLC genetic mutations.
Sotorasib achieved a response rate across all trial subgroups in the recently announced research results of the phase 2 CodeBreaK 100 trial.
Healthcare personnel’s understanding of patients’ feelings and empathy, along with steps to improve patients’ resilience, are seen as the most important factors in maintaining patients with cancer’s mental state, including maintaining their levels of anxiety and depression.
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