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FDA Grants Priority Review to Application for Pembrolizumab Monotherapy as First-Line Treatment of Locally Advanced or Metastatic Non–Small Cell Lung Cancer in Patients Whose Tumors Express PD-L1 (TPS ≥1%)
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Entrectinib achieved high response rates as well as durable responses in patients with ROS1-positive non–small cell lung cancer (NSCLC), including patients with brain metastases, according to a pooled analysis of phase 1 and 2 trials.
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Atezolizumab combined with carboplatin/etoposide represents a new standard of care for first-line treatment of extensive-stage small cell lung cancer (ES-SCLC), according to results from the phase 3 IMpower133 trial presented at the IASLC 19th World Conference on Lung Cancer.
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Brigatinib significantly prolonged survival compared with crizotinib (standard of care) as first-line therapy in patients with advanced anaplastic lymphoma kinase (ALK)-positive non–small cell lung cancer (NSCLC).
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The combination of nivolumab plus ipilimumab extended progression-free survival (PFS) versus stan­dard chemotherapy as first-line treatment for patients with advanced non–small cell lung cancer (NSCLC) with a high tumor mutational burden (TMB).
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A burning question is whether immunotherapy combinations will further improve outcomes over checkpoint inhibitor therapy alone; and if so, which combinations will rise to the top.
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The following research abstracts in lung cancer were accepted by the Academy of Oncology Nurse & Patient Navigators for the 2018 Annual Conference. We congratulate the authors on their work and the impact they have had on the field of navigation.
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Clinical Relevance and Rationale of Using MSI-H/dMMR Biomarkers in Immunotherapy of Colorectal Cancer and Other Solid Tumors

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Journal of Oncology Navigation & Survivorship
JONS

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