Breast Cancer

May 2026 Vol 17, No 3 — May 1, 2026
Clinical trials hold the promise of groundbreaking treatments, but the pathways to participation can be daunting. Learn how navigators are empowering patients to overcome barriers, ask the right questions, and confidently explore life-changing opportunities.

December 2025 Vol 16, No 12 — December 5, 2025
Explore the unique challenges faced by young patients with breast cancer and learn how innovative navigation programs are bridging gaps in care and empowering patients to thrive.

Identification and Treatment of Patients With Hormone Receptor–Positive, HER2-Negative Early Breast Cancer at High Risk of Recurrence: monarchE Study Long-Term Outcomes
Special Issues and Supplements — February 24, 2025
We are pleased to announce the release of our next issue of Clinical Trials to Clinical Practice. This article provides expert commentary from Joyce A. O’Shaughnessy, MD, on the use of endocrine therapy with or without adjuvant abemaciclib for patients with high-risk, hormone receptor (HR)-positive, HER2-negative early breast cancer.

Navigator Guide: Walking With a Patient Down the Early Breast Cancer Path
Resources — September 9, 2024
The Navigator Guide: Walking With a Patient Down the Early Breast Cancer Path is a resource that oncology nurses and navigators can use to assist patients and caregivers in the fight against early-stage breast cancer. Oncology nurses and navigators guide patients through their treatment journey from time of diagnosis into survivorship, providing education, resources, and support.


A Guide Through the Metastatic Breast Cancer Patient Journey: Focus on HER2+/HER2-Low ADC Therapy
Resources — February 27, 2024
In partnership with Daiichi Sankyo, this roadmap is intended to provide a comprehensive overview and educational resource for advanced practice providers (Nurse Practitioner, Pharmacist, Physician Assistant) and oncology nurse navigators on HER2+/HER2-low breast cancer including key considerations for treatment, setting upfront expectations, and adverse event management.

Evolving Adjuvant Treatment Landscape for HR+/HER2- Early Breast Cancer
Video Library — December 18, 2023
This first installment observes how the adjuvant treatment landscape has evolved for patients with HR+/HER2- early breast cancer, including discussion on the monarchE study.

Key Breast Cancer Abstracts in 2023 and Innovations in Ovarian Function Suppression:
Video Library — August 14, 2023
Please join Sara Tolaney, MD, MPH, Dana-Farber Cancer Center, Boston, MA; Erica Stringer-Reasor, MD, University of Alabama, Birmingham; and Matteo Lambertini, MD, PhD, University of Genoa, Italy, as they provide expert commentary on key breast cancer abstracts presented at the 2023 ASCO Annual Meetings that will impact young women with ER+/HER2- breast cancer.

Navigating Oral Therapy in Breast Cancer: Practice Strategies to Promote Medication Adherence
Video Library — November 9, 2022
The Academy of Oncology Nurse & Patient Navigators (AONN+) and Eli Lilly and Company Medical Affairs are pleased to present a live webinar designed to facilitate conversations with patients regarding adherence to breast cancer treatments. Attendees will have an opportunity to participate in a live Q&A following the presentation.

September 2022 Vol 13, No 9 — September 19, 2022
Oral oncolytic drugs have a multitude of benefits for patients, including ease of use, improved quality of life, fewer clinic visits, and no need for IV therapy.



Patients with endocrine-resistant HR-positive/HER2-negative metastatic breast cancer require novel therapeutic alternatives as a result of the poor outcomes of currently available later-line medications.

The emergence of innovative targeted therapy in combination with endocrine therapy has shown improvement in HR-positive breast cancer results, but the US Food and Drug Administration–approved combinations all include endocrine therapies in their regimens, leaving an unmet need in patients who develop endocrine resistance.


Abemaciclib plus nonsteroidal aromatase inhibitors were shown to be a successful initial treatment in a Japanese subpopulation, with a tolerable safety profile, consistent with findings in the whole population in treating patients with HR-positive, HER2-negative advanced breast cancer.

The therapeutic advantage of alpelisib over fulvestrant in the treatment of patients with HR-positive, HER2-negative breast cancer and other malignancies is further enhanced by a matched/weighted analysis comparing BYLieve with the real-world scenario.

Endocrine therapy used in combination with CDK4/6 inhibitors, in particular, have transformed the metastatic breast cancer landscape, promisingly improving progression-free survival and overall survival among patients with HR-positive, HER2-negative metastatic breast cancer.

Neoadjuvant chemotherapy is becoming more popular for patients with locally advanced breast cancer. Downstaging may result in a smaller surgical extent or a higher breast conservation rate, and a better cosmetic outcome. Chemotherapy, on the other hand, has both short- and long-term complications.

Treatment with ICIs in metastatic TNBC has shown encouraging results. Immunotherapy has shifted the paradigm of cancer treatment and opened new research opportunities. TNBC is characterized by immunologic activation while being the most common subtype of breast cancer.

Along with surgery, radiation, chemotherapy, and targeted therapy, immunotherapy has emerged as the fifth pillar of cancer treatment and is revolutionizing cancer treatment across the board.

Sacituzumab govitecan is an effective new medication for people with metastatic TNBC that is well-tolerated. The most prevalent side effects seen in individuals with metastatic TNBC using sacituzumab govitecan are similar to those seen with chemotherapy and can be managed with early, proactive intervention.

SASCIA was a phase 3 trial evaluating sacituzumab govitecan, an antibody–drug conjugate that received accelerated approval from the FDA in 2020 for the treatment of patients with metastatic TNBC who have received ≥2 previous therapies for metastatic disease.

In October 2021, trastuzumab deruxtecan was granted Breakthrough Therapy Designation by the FDA in the United States for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received ≥1 previous anti-HER2–based regimens.

Two new antibody–drug conjugates with a topoisomerase I inhibitor payload have recently been added to the therapy options for patients with metastatic TNBC and HER2-positive breast cancer.

PARP inhibitors and immune checkpoint inhibitors have changed the breast cancer landscape, with trials that show improved progression-free survival and overall survival.

Improved knowledge of the biologic pathways, along with a number of new targeted therapies, has resulted in better outcomes for patients with HR-positive, HER2-negative breast cancer. These new therapies have been used in combination with older treatments to optimize patient outcomes.

CDK4/6 inhibitors in combination with antiestrogen therapy are the standard of care for HR-positive, HER2-negative advanced breast cancer. However, a diverse landscape of resistance to these therapies exists, which has resulted in precision-guided therapeutic strategies that are under active clinical development.

Olaparib monotherapy has shown promising clinical results in treatment-naïve TNBC with germline or somatic homologous repair deficiency, with fewer adverse events compared with traditional chemotherapy.


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Journal of Oncology Navigation & Survivorship
JONS

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