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Real-world outcomes from a retrospective, single-center study suggested that pegfilgrastim or its biosimilar pegfilgrastim-cbqv does not increase febrile neutropenia or delayed engraftment risk in patients with lymphoma and CLL and may be safe to use after administration of chemotherapy.

The results of a retrospective, single-center analysis demonstrated that same-day pegfilgrastim or pegfilgrastim-cbqv was safe and effective in patients with diffuse large B-cell lymphoma who received a rituximab plus miniCHOP chemotherapy regimen, with no significant increase in febrile neutropenia or delayed engraftment.

Real-world evidence demonstrated that the characteristics of patients with metastatic colorectal cancer who received bevacizumab-awwb in the first year after product launch were similar regardless of prior bevacizumab use, and that beva­cizumab-awwb was used in new and continuing patients.

An observational study indicates that the Oncology Care Model led to reduced use of some high-cost supportive care medications, suggesting the potential for alternative payment models to drive value-based changes in cancer medication use.

The findings of a simulation modeling analysis demonstrate that conversion from pegfilgrastim with on-body injector to pegfilgrastim-jmdb provides significant cost-savings, which could be reallocated on a budget-neutral basis to provide expanded access to additional prophylaxis or to antineoplastic therapy in patients with diffuse large B-cell lymphoma.

A pharmacokinetic study demonstrated bioequivalence between SB12 and the eculizumab reference products, along with comparable pharmacodynamics, safety, and immunogenicity.

The preliminary results of a phase 2 study indicate that the combination of rituximab biosimilar plus pegylated interferon α-2b was well-tolerated and yielded responses in newly diagnosed advanced indolent B-cell NHL.

A biosimilar adoption integration process that included full staff education, physician consent, and systematic auto- conversion proved to be feasible and scalable, and resulted in rapid conversion from reference product to FDA-approved biosimilar.

A retrospective, cross-sectional review reported significant uptake of biosimilar filgrastim products in Medicare Part D from 2015 to 2019 being associated with a small decrease in aggregate spending, essentially unchanged per-unit spending, and increased spending per beneficiary on filgrastim products, all attributed to the inability of Medicare Part D to directly negotiate prices with manufacturers.

Prospective evaluation of real-world biosimilar-related cost-savings and adoption indicates that biosimilar utilization in community oncology practices can result in significant cost-savings.