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Category VII: Clinical Research

Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

43. A Novel Approach for 2-Stage Breast Reconstruction: Patient-Controlled Tissue Expansion Using the AeroForm CO2 Tissue Expander System

Jenny Saldaña, BA, Patient Navigator and Breast Cancer Survivor
Columbia Presbyterian Medical Center 

Objectives: The tissue expansion process using standard of care, saline-filled expanders is lengthy, inconvenient, and uncomfortable and may lead women to make the decision to decline breast reconstruction. The efficacy [ Read More ]

Category VII: Clinical Research

44. Decision-Making in Cancer Research

Barbara Biedrzycki, PhD, CRNP, AOCNP
Johns Hopkins 

Background: Cancer clinical research is essential to producing evidence-based clinical care that offers better treatment outcomes. Yet the recruiting and consenting process for cancer clinical trials can be challenging and [ Read More ]

Breast Cancer, Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

45. Eight Case Studies of Concurrent Pathogenic Mutations Identified in Hereditary Breast and Ovarian Cancer Gene Panel

Lilian Servais, MS, LCGC; Lauren Ryan, MS, LCGC; Jeroen Van den Akker, PhD; Annette Leon, PhD, MS, FACMG
Color Genomics 

Objectives: The availability of next-generation sequencing (NGS) and characterization of multiple genes that can increase cancer risk have caused a shift toward multigene panel testing for hereditary cancer. However, the [ Read More ]

Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

46. Interdisciplinary Management of Chemorefractory NHL Patients Treated with KTE-C19 (Anti-CD19 CAR T Cells) in Phase 1 of the ZUMA-1 Clinical Study

Alix Beaupierre,1 Amy Patterson,1 Nicole Kahle,1 Frederick L. Locke,1 Sattva S. Neelapu,2Nancy L. Bartlett,3 Tanya Siddiqi,4 Julio C. Chavez,5 Chitra M. Hosing,6 Amanda Cashen,3 Lihua E. Budde,4 Lynn Navale,7 Yizhou Jiang,7 Meg Elias,7 Jeff Aycock,7 Jeff Wiezorek,7 William Y. Go7
1Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, FL; 2Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX; 3Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO; 4Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA; 5Department of Malignant Hematology, Moffitt Cancer Center, Tampa, FL; 6Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX; 7Kite Pharma, Santa Monica, CA 

Objectives: Patients with chemorefractory non-Hodg­kin lymphoma (NHL) have poor response to standard therapy and short overall survival. The objectives of the phase 1 ZUMA-1 trial were to evaluate the safety [ Read More ]

Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

47. Prevention of Everolimus/Exemestane (EVE/EXE) Stomatitis in Postmenopausal (PM) Women with Hormone Receptor–Positive (HR+) Metastatic Breast Cancer (MBC) Using a Dexamethasone-Based Mouthwash (MW): Results of the SWISH Trial

Lindsay Shelby, RN, OCN1; Hope S. Rugo, MD2; Lasika Seneviratne, MD3; John A. Glaspy, MD4; Julio A. Peguero, MD5; Timothy J. Pluard, MD6; Navneet Dhillon, MD7; Leon C. Hwang, MD8; Chaitali Nangia, MD9; Ingrid A. Mayer, MD10; Timothy F. Meiller, DDS11; Mark S. Chambers, DMD12; Jaqueline Rogerio, MD13; Kristina Wagner, MS13; Robert W. Sweetman, MD13; J. Randy Sabo13; J. Thaddeus Beck, MD1 Columbia Presbyterian Medical Center

1Highlands Oncology Group, Rogers, AR; 2University of California San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA; 3Los Angeles Cancer Network, Los Angeles, CA; 4University of California Los Angeles School of Medicine, Los Angeles, CA; 5Oncology Consultants P.A., Department of Research, Houston, TX; 6St. Luke’s Cancer Institute, Kansas City, MO; 7Cancer Treatment Centers of America, Atlanta, GA; 8Kaiser Permanente Mid-Atlantic States, Gaithersburg, MD; 9UC Irvine Health Chao Family Comprehensive Cancer Center, Orange, CA; 10Vanderbilt-Ingram Comprehensive Cancer Center, Nashville, TN; 11Oncology and Diagnostic Sciences, Dental School and The Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD; 12The University of Texas MD Anderson Cancer Center, Houston, TX; 13Novartis Pharmaceutical Corporation, East Hanover, NJ
 

Objective: Stomatitis is a common adverse event (AE) of mTOR inhibition. In BOLERO-2, all-grade (Gr), Gr ≥2 and 3 stomatitis incidence with EVE/EXE was 67%, 33%, and 8%, respectively. Median [ Read More ]

Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

48. Restoring Quality of Life and Hematologic Function with Ibrutinib in Treatment-Naive Patients with Chronic Lymphocytic Leukemia in the RESONATE-2 Study

Sara Deisinger, RN, BSN1; Edythe Greenberg, NP2; Cathy Zhou, MS3; Lori Styles, MD3; Danelle James, MD3; Jan A. Burger, MD, PhD2; Paul M. Barr, MD1
1Wilmot Cancer Institute, University of Rochester, Rochester, NY; 2The University of Texas MD Anderson Cancer Center, Houston, TX; 3Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA 

Objectives: Disease symptoms and treatment complications can profoundly affect quality of life (QOL) in patients (pts) with chronic lymphocytic leukemia (CLL). Ibrutinib (ibr), a B-cell receptor pathway inhibitor, improved QOL [ Read More ]

Category VII: Clinical Research, Seventh Annual AONN+ Conference Abstracts

49. The Association Between Guideline-Recommended Treatment Initiation, Healthy Days, and Patient-Reported Symptoms in Patients with Non–Small Cell Lung Cancer

Adrianne W. Casebeer, PhD, MPP, MS1; Dana Drzayich Antol, MS1; Yong Li, PhD1; Richard W. DeClue, PhD1; Sari Hopson, PhD, MSPH1; Raya Khoury, MPH2; Aparna Parikh, MD2; Alisha Stein, RN-NC, MSN, OCN2; Todd Michael, PharmD, RPh2; Stephen Stemkowski, PhD, MHA1; Mikele Bunce, PhD, MPH2
1Comprehensive Health Insights, Humana Inc, Louisville, KY; 2Genentech Inc, South San Francisco, CA 

Objectives: Previous studies have suggested that guideline-recommended therapy improves survival and reduces cost among patients with metastatic non–small cell lung cancer (mNSCLC). The purpose of this study was to explore [ Read More ]